Definition of Cultural Fatigue:

‘Cultural fatigue is the physical and emotional exhaustion that almost invariably results from the infinite series of minute adjustments required for long-term survival in an alien culture. Living and working overseas generally requires that one must suspend his automatic evaluations and judgements; that he must supply new interpretations to seemingly familiar behaviour and that he must demand of himself constant alternations in the style and content of his activity. Whether this process is conscious or unconscious, successful or unsuccessful, it consumes an enormous amount of energy, leaving the individual decidedly fatigues…’

Cultural Confrontation in the Philippines, David L. Szanton